Napoli will very much be looking to bounce back after their first defeat of the season to Juventus and subsequently getting knocked out the Champions league in midweek.
Both sides go for 4-3-3 systems which creates an intriguing match up of who can get the better of the game.
Fiorentina: (4-3-3) Sportiello; Laurini, Pezzella, Astori, Biraghi; Veretout, Badelj; Chiesa, Benassi, Théréau; Simeone.
Stefano Pioli names an unchanged team from the side who beat Sassuolo 3-0. Simeone will lead the line and be looking to add to his five goals this season. Fiorentina have Cyril Thereau alongside him looking to keep his impressive season going.
Napoli: (4-3-3) Reina; Hysaj, Albiol, Koulibaly, Mario Rui; Allan, Jorginho, Hamsik; Callejon, Mertens, Zielinski
Napoli are without key player Lorenzo Insigne who was injured against Feyenoord. Zelinski will be part of the front three including the dangerous Jose Callejon and Dries Mertens.
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