Both Mauricio Pochettino and Paulo Sousa named their expected sides.
The match was once again more about energy than technique, with both sides pressing energetically from the word go. Spurs had the advantage in territory, but Fiorentina got the ball into threatening positions as well, although neither side manufactured many clear chances until Delle Ali put Ryan Mason through on goal, and the England international finished coolly across Ciprian Tătăruşanu in the 25th minute.
The rest of the half continued in much the same vein, with Josip Iličić coming closest to equalizing for Fiorentina.
The pattern of the game didn't change until the 63rd minute, when Erik Lamela eventually lashed a rebound past Tătăruşanu.
All the fight seemed to go out of Fiorentina, summed up by Gonzalo Rodríguez turning a Mason cross into his own goal in the 81st minute to complete the rout.
With Napoli also bowing out at the hands of Villarreal, this defeat hurts Italy's coefficient, especially as the loss came to an English team. However, it does allow Sousa to focus exclusively on Serie A for the remainder of the season, and may provide the impetus for a permanent switch to the 4-2-3-1.